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张一宁，讲师。2019年6月本科毕业于a片动画 a片动画 药学专业，2024年6月博士毕业于a片动画 药物化学专业。主要从事肿瘤靶向小分子荧光探针的设计、合成与评价；小分子药物偶联物(SMDC)的设计、合成与评价；肿瘤免疫治疗药物的开发。

主持参与科研项目：

1. 河北省高等学校科学技术研究项目，QN2025392，新型肿瘤靶向NIR-Ⅱ小分子荧光探针的研究，2025.01-2027.12，主持

2. 国家自然科学基金面上项目，82073681，设计合成FR-β/PI3Kγ靶向嵌合分子调控TAM极化作用及抗肿瘤免疫机制研究，2021.01-2024.12，参与

代表论文：

1. Lixiao Guo, Binghao Guo, Yuqing Wang, Yuwei Zheng, Shuo Sun, Mengqi WuYingao Li, Deguang Jiang, Ruijuan Xing, Zenghui Sun, Yan Fu, Xin Li, Yining Zhang*, Yi Liu*, Lei Wang*. Design and Synthesis of FR-β Targeting Chimeric Molecules for Reprogramming Tumor-Associated Macrophages Using 6-Substituted Pyrrolo[2,3-d]pyrimidines As Targeting Ligands. Journal of Medicinal Chemistry 2025; 68(8): 8295-8309.

2. Yining Zhang, Zijun Luo, Lixiao Guo, Haofeng Zhang, Tongdan Su, Zhenzhen Tan, Qian Ren, Can Zhang, Yan Fu, Ruijuan Xing, Ran Guo, Xiaowei Shi, Huicai Guo, Yi Liu*, and Lei Wang*. Discovery of Novel Tumor-Targeted near-Infrared Probes with 6-Substituted Pyrrolo[2,3-d]Pyrimidines as Targeting Ligands. European Journal of Medicinal Chemistry 2023, 262, 115914. 

3. Zenghui Sun, Shilin Xue, Yining Zhang, Shiyang Xin, Ran Guo, Xiaowei Shi, Yan Fu, Huicai Guo, Yi Liu, and Lei Wang*. λ3-Iodane/Lewis acid mediated intramolecular cross-nucleophile coupling of β-amino acrylates: chemodivergent syntheses of indole alkaloidal frameworks. Organic Letters 2022, 24, 5381-5385. 

4. Ran Guo, Miao Cui, Xiaojing Li, Mengqi Wu, Fei Xu, Yining Zhang, Chun Wang, Penglei Feng, Jianchao Wang, Sijia Huo, Zijun Luo, Ruijuan Xing, Jianmin Gu, Xiaowei Shi*, Yi Liu*, and Lei Wang*. Design, Synthesis and Biological Evaluation of Pyrrolopyrimidine Derivatives as Novel and Selective Positive Modulator of the Small Conductance Ca2+-Activated K+ Channels. European Journal of Medicinal Chemistry 2023, 254, 115353.